The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior.Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established.However, the implications of its receptors in lung adenocarcinoma have so far remained

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ENDNet: Extra-Node Decision Network for Subgraph Matching

Subgraph matching, which involves identifying a query graph within a larger data graph, is a fundamental problem that has applications in various fields.Although graph neural networks (GNNs) are commonly used in learning-based subgraph matching, they face challenges due to their convolution process.Specifically, GNNs generate new node features by a

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360 Degrees of Segregation: A Historical Perspective Of Segregation-era School Equalization Programs In the Southern United States

The modern school finance litigation movement in the United States is largely based on the presumption that school funding is correlative to the academic success of poor and minority children.Although the start of this movement is generally recognized as beginning in Dongs 1971 , its more notable precursors are the southern school equalization prog

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